Chloroquine phosphate synthesis

Other animals Feb 7, 2020 · The DMARDs hydroxychloroquine and chloroquine are weak bases that accumulate in acidic compartments such as lysosomes and inflamed (acidic) tissues. Chloroquine (CQ), a protonated, weakly basic drug, exerts its antimalarial effect mainly by increasing pH and accumulating in the food vacuole of the parasites

2024-03-29
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  1. S
  2. Quinoline (QN) derivatives are often used for the prophylaxis and
  3. Chloroquine can be synthesized by reaction of 4,7