Moderate See more Monoamine oxidase inhibitors (MAOIs) Monoamine oxidase inhibitors
Off-label uses include supraventricular tachycardia and thyroid storm
Metoprolol (a CYP2D6 substrate) is often co-prescribed with paroxetine/fluoxetine (a CYP2D6 inhibitor) because the clinical relevance of this drug–drug interaction (DDI) is still unclear
Metoprolol should not be used concomitantly with paroxetine, fluoxetine or bupropion due to extensive interactions and the risk of serious adverse effects
Common medications that may interact with metoprolol include: antidepressants, such as fluoxetine, paroxetine, St John’s Wort, and monoamine
Interaction of metoprolol and fluoxetine
How it works Metoprolol succinate is a heart medication that works by blocking the effects of epinephrine on beta-1 receptors within the heart tissue, causing
Metoprolol is a common medication used by the elderly because it is affordable and has proven to decrease mortality in cardiovascular disease such as
Contact your doctor if you experience uneven heartbeats, shortness of breath, bluish-colored fingernails, dizziness, weakness, fainting, or seizure (convulsions)
The nitrite-oxidizing consortium presented the lowest biodegradation of the How metoprolol works
Contact your doctor if your condition changes or you experience increased side effects
Common interactions include urinary tract infection among females, and asthenia among males
Side Effects
Descriptions
Therefore, it might be interesting to further investigate the outcomes of the interacting drugs in different genotype statuses
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In fact, one study found that about one-third of people who had nightmares were taking a beta blocker
Metoprolol Succinate ER (metoprolol) Metoprolol Succinate ER (metoprolol) Synthroid (levothyroxine) Synthroid Purpose: Co-prescription of paroxetine/fluoxetine (a strong CYP2D6 inhibitor) in metoprolol (a CYP2D6 substrate) users is common, but data on the clinical consequences of this drug-drug interaction are limited and inconclusive
Lowering high blood pressure helps prevent strokes, heart attacks , and kidney problems
Metoprolol succinate extended-release tablets may be administered with other antihypertensive agents
Fluoxetine comes as a capsule, a tablet, a delayed-release (releases the medication in the intestine) capsule, and a solution (liquid) to take by mouth
This preferential effect is not absolute, however, and at higher plasma concentrations, metoprolol also inhibits beta 2-adrenoreceptors, chiefly located in the bronchial and vascular musculature
At the time I was prescribed Norpace (dysopyramide) to keep my heart rate from dropping so low during an attack and that fairly well "cured" me
The heart rate slowing may or may not be profound but results in a heart rate that is slower than appropriate for the falling blood pressure, leading to systemic hypotension and cerebral hypoperfusion Prednisone