6 to 1
25 The half-life in patients who do not pass urine, usually due to renal failure, is prolonged to 3
0625 mg) daily or less may suffice
5–4 mcg/kg twice daily
One-half or one-third is given first and the remainder in equal portions every 6 to 8
10
Studies show that digoxin use is declining but is still prevalent
Digoxin is extensively distributed in the tissues, as reflected by the large volume of distribution
Serious side
Digoxin is one of the oldest medications used in the field of cardiology
Because it has a relatively long elimination half-life in adults, digoxin is given once daily
0 days
Sampling for digoxin concentrations should be performed no sooner than 8 hours after the last dose
Digoxin is a cardiac glycoside with positive inotropic and negative chronotropic actions
LASIX tablets for oral administration contain furosemide as the active ingredient and the following inactive ingredients: lactose monohydrate NF, magnesium stearate NF, starch NF, talc USP, and colloidal silicon dioxide NF
, 1984), digoxin had a half-life of 37
In healthy volunteers with normal renal function, digoxin has a half-life of 1
Digoxin is not effectively removed from the body by dialysis, exchange transfusion, or during cardiopulmonary bypass because most of the drug is bound to tissue and does not circulate in The long half-life of digoxin distinguishes this drug from most other cardiovascular acting drugs
Following oral administration, digoxin is rapidly absorbed and the median distribution half-life is 0
Must be administered by continuous IV infusion because brief half-life
The measurement of digoxin levels should be performed 6–8 h after the last dose of digoxin
33 for pre-term babies and 0
Treatment A
Factors that increase the likelihood of digoxin toxicity: Hypokalemia, hypomagnesemia, hypothyroidism, renal dysfunction, interacting drugs (eg quinidine, verapamil)
0 µg/L
7 ng/mL and has been shown to be more accurate than the traditional Jellife or Koup and Jusko methods
Digoxin increases myocardial contraction, which increases cardiac output
Question: if digoxin has a half - life of 35 hous how long will it take for toxic plasma concentration of 8 ng/ ml to decline to theapeuticc plasma concentration of 2 ng/ ml
Concentrations >1
3 days, respectively, which are significantly less than the respective serum half-lives of 2